Metabolism: Oxycodone hydrochloride is extensively metabolized to noroxycodone, oxymorphone, and their glucuronides. The foremost circulating metabolite is noroxycodone with an AUC ratio of 0.The concomitant use of OXYCONTIN and CYP3A4 inhibitors can improve the plasma concentration of oxycodone, causing improved or prolonged opioid outcomes.Conver